Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation

Abstract Bone resorption is driven through osteoclast differentiation by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-Β ligand (RANKL). We noted that a disintegrin and metalloproteinase (ADAM) 10 and ADAM17 are downregulated at the expression level duri...

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Autori principali:	Aaron Babendreyer, Julia Kieselhorst, Cindy Rinkens, Anastasia M. Lyashenko, Stefan Düsterhöft, Holger Jahr, Rogerio B. Craveiro, Michael Wolf, Andreas Ludwig
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-06-01
Serie:	Cell Communication and Signaling
Soggetti:	Osteoclast Monocyte Metalloproteinase Shedding Colony stimulating factor 1 receptor Receptor activator of nuclear factor kappa-Β ligand
Accesso online:	https://doi.org/10.1186/s12964-024-01690-y
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