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DNA G-Quadruplexes as Targets for Natural Product Drug Discovery

DNA guanine (G)-quadruplexes (G4s) are unique secondary structures formed by two or more stacked G-tetrads in G-rich DNA sequences. These structures have been found to play a crucial role in highly transcribed genes, especially in cancer-related oncogenes, making them attractive targets for cancer t...

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Principais autores: Kai-Bo Wang, Yingying Wang, Jonathan Dickerhoff, Danzhou Yang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-07-01
Serier:Engineering
Fag:
G-quadruplex
Natural products
Alkaloids
Cancer
Promoter
Online adgang:http://www.sciencedirect.com/science/article/pii/S2095809924002467
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