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O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans

Neurodevelopmental disorders such as epilepsy and autism have been linked to an imbalance of excitation and inhibition (E/I) in the central nervous system. The simplicity and tractability of C. elegans allows our electroconvulsive seizure (ES) assay to be used as a behavioral readout of the locomoto...

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Autors principals: Nirthieca Suthakaran, Jonathan Wiggins, Andrew Giles, Karla J. Opperman, Brock Grill, Ken Dawson-Scully
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2021-01-01
Col·lecció:PLoS ONE
Accés en línia:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604358/?tool=EBI
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