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Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction

Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow skeletal muscle share a common isoform of the trop...

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Principais autores: Zabed Mahmud, Svetlana Tikunova, Natalya Belevych, Cory S. Wagg, Pavel Zhabyeyev, Philip B. Liu, David V. Rasicci, Christopher M. Yengo, Gavin Y. Oudit, Gary D. Lopaschuk, Peter J. Reiser, Jonathan P. Davis, Peter M. Hwang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-06-01
coleção:Frontiers in Physiology
Assuntos:
cardiac troponin activator
calcium sensitizer
inotrope
systolic heart failure
striated muscle
thin filament
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphys.2022.892979/full
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