Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction

Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow skeletal muscle share a common isoform of the trop...

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主要な著者:	Zabed Mahmud, Svetlana Tikunova, Natalya Belevych, Cory S. Wagg, Pavel Zhabyeyev, Philip B. Liu, David V. Rasicci, Christopher M. Yengo, Gavin Y. Oudit, Gary D. Lopaschuk, Peter J. Reiser, Jonathan P. Davis, Peter M. Hwang
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2022-06-01
シリーズ:	Frontiers in Physiology
主題:	cardiac troponin activator calcium sensitizer inotrope systolic heart failure striated muscle thin filament
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fphys.2022.892979/full
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