Reducing stress and alcohol-related behaviors by targeting D1-CRHR1 receptor interactions in the amygdala

BackgroundBasic neuroscience has identified dopamine and corticotropin-releasing hormone (CRH) systems and amygdala circuits as key contributors to drug and alcohol reward, craving, and relapse. However, directly targeting these systems has had no impact on the treatment of addictive disorders. CRH...

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Bibliografski detalji

Glavni autori:	Laura Broccoli, Rick E. Bernardi, Francesco Giannone, Anika Hoppe, Kay Jungling, Dasiel O. Borroto-Escuela, Roberto Rimondini-Giorgini, Miguel Pérez de la Mora, Oliver von Bohlen und Halbach, Kjell Fuxe, Hans-Christian Pape, Jan M. Deussing, Rainer Spanagel, Wolfgang H. Sommer, Anita C. Hansson
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2025-10-01
Serija:	Frontiers in Pharmacology
Teme:	intercalated amygdalar cells corticotropin releasing factor 1 receptor dopamine D1 receptor (D1R) alcohol use disorder (AUD) amygdala stress and anxiety
Online pristup:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1677510/full
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