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Reducing stress and alcohol-related behaviors by targeting D1-CRHR1 receptor interactions in the amygdala

BackgroundBasic neuroscience has identified dopamine and corticotropin-releasing hormone (CRH) systems and amygdala circuits as key contributors to drug and alcohol reward, craving, and relapse. However, directly targeting these systems has had no impact on the treatment of addictive disorders. CRH...

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Principais autores: Laura Broccoli, Rick E. Bernardi, Francesco Giannone, Anika Hoppe, Kay Jungling, Dasiel O. Borroto-Escuela, Roberto Rimondini-Giorgini, Miguel Pérez de la Mora, Oliver von Bohlen und Halbach, Kjell Fuxe, Hans-Christian Pape, Jan M. Deussing, Rainer Spanagel, Wolfgang H. Sommer, Anita C. Hansson
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-10-01
coleção:Frontiers in Pharmacology
Assuntos:
intercalated amygdalar cells
corticotropin releasing factor 1 receptor
dopamine D1 receptor (D1R)
alcohol use disorder (AUD)
amygdala
stress and anxiety
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2025.1677510/full
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