Investigating therapeutic response to netarsudil in glaucoma subjects with the ARHGEF12 risk variant

IntroductionARHGEF12 variants, which regulate the RhoA/ROCK pathway, are associated with primary open-angle glaucoma (POAG) in individuals of African ancestry and may influence response to Rho-kinase inhibitors such as netarsudil.MethodsWe analyzed 1,844 African ancestry subjects with POAG, comparin...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Anusha Mamidipaka, Isabel Di Rosa, Marine-Ayan Ibrahim Aibo, Fangming Jin, Rebecca Salowe, Roy Lee, Mina Halimitabrizi, Leila Ghaffari, Victoria Addis, Laxmi Moksha, Gui-Shuang Ying, Joan M. O’Brien
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-05-01
Serie:	Frontiers in Pharmacology
Soggetti:	ARHGEF12 netarsudil neuroprotection primary open-angle glaucoma Rho kinase (ROCK) inhibitor Rho/ROCK pathway
Accesso online:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1803432/full
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!