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Investigating therapeutic response to netarsudil in glaucoma subjects with the ARHGEF12 risk variant

IntroductionARHGEF12 variants, which regulate the RhoA/ROCK pathway, are associated with primary open-angle glaucoma (POAG) in individuals of African ancestry and may influence response to Rho-kinase inhibitors such as netarsudil.MethodsWe analyzed 1,844 African ancestry subjects with POAG, comparin...

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Main Authors: Anusha Mamidipaka, Isabel Di Rosa, Marine-Ayan Ibrahim Aibo, Fangming Jin, Rebecca Salowe, Roy Lee, Mina Halimitabrizi, Leila Ghaffari, Victoria Addis, Laxmi Moksha, Gui-Shuang Ying, Joan M. O’Brien
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2026-05-01
Series:Frontiers in Pharmacology
Subjects:
ARHGEF12
netarsudil
neuroprotection
primary open-angle glaucoma
Rho kinase (ROCK) inhibitor
Rho/ROCK pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2026.1803432/full
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