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TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia

Abstract Background Cancer cells show increased glycolysis and take advantage of this metabolic pathway to generate ATP. The TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits aerobic glycolysis and protects tumor cells from intracellular reactive oxygen species (ROS)-associated apopto...

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Principais autores: Sixuan Qian, Jianyong Li, Ming Hong, Yu Zhu, Huihui Zhao, Yue Xie, Jiayu Huang, Yun Lian, Yanru Li, Shuai Wang, Jianping Mao, Yaoyu Chen
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2016-11-01
Series:Journal of Hematology & Oncology
Assuntos:
TIGAR
Glycolysis
Acute myeloid leukemia
Apoptosis
Survival
Acceso en liña:http://link.springer.com/article/10.1186/s13045-016-0360-4
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