TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia

Abstract Background Cancer cells show increased glycolysis and take advantage of this metabolic pathway to generate ATP. The TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits aerobic glycolysis and protects tumor cells from intracellular reactive oxygen species (ROS)-associated apopto...

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Autors principals:	Sixuan Qian, Jianyong Li, Ming Hong, Yu Zhu, Huihui Zhao, Yue Xie, Jiayu Huang, Yun Lian, Yanru Li, Shuai Wang, Jianping Mao, Yaoyu Chen
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2016-11-01
Col·lecció:	Journal of Hematology & Oncology
Matèries:	TIGAR Glycolysis Acute myeloid leukemia Apoptosis Survival
Accés en línia:	http://link.springer.com/article/10.1186/s13045-016-0360-4
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