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Multi-drug pharmacotyping improves therapy prediction in pancreatic cancer organoids

Abstract Patient-Derived Organoids (PDOs) represent a promising technology for therapy prediction in pancreatic cancer, with the potential of enhancing treatment outcomes and allowing more effective, personalized treatment choices. However, classification approaches into sensitive and resistant mode...

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Главные авторы: Katharina Wansch, Uwe Pelzer, François Schneider, Florian Dölvers, Anna Kühn, Mihnea P. Dragomir, Jana Ihlow, Georg Hilfenhaus, Loredana Vecchione, Matthäus Felsenstein, Dou Ma, Markus Lerchbaumer, Christian Jürgensen, Marcus Bahra, Adrian E. Granada, Gregor Duwe, Sebastian Stintzing, Ulrich Keilholz, Christopher C. M. Neumann
Формат: Artigo
Язык:Inglês
Опубликовано: BMC 2025-09-01
Серии:Cancer Cell International
Предметы:
Pancreatic adenocarcinoma
Patient-derived organoids
Multi-Drug response metrics
Pharmacokinetic modelling
Online-ссылка:https://doi.org/10.1186/s12935-025-03969-7
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