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Genomic approach to evaluate the intrinsic antibacterial activity of novel diazabicyclooctanes (zidebactam and nacubactam) against clinical Escherichia coli isolates from diverse clonal lineages in the United Arab Emirates

Background: The spiking rise in the prevalence of multidrug-resistant (MDR) pathogens necessitates discovering new antimicrobial agents. This study aims to investigate the intrinsic activity of two novel diazabicyclooctane (DBO) β-lactamase inhibitors, zidebactam and nacubactam, against diverse MDR...

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Autori principali: Farah Al-Marzooq, Akela Ghazawi, Maitha Alshamsi, Abdulrahman Alzaabi, Omar Aleissaee, Hamad Almansoori, Abdullah Alsaadi, Rauda Aldhaheri, Hafsa Ahli, Lana Daoud, Amna Ahmad, Timothy Collyns, Seema Oommen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2025-06-01
Serie:Journal of Infection and Public Health
Soggetti:
Diazabicyclooctanes
Zidebactam
Nacubactam
Escherichia coli
Whole-genome sequencing
Accesso online:http://www.sciencedirect.com/science/article/pii/S1876034125001108
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