High efficacy and enhanced synergistic activity of the novel siderophore-cephalosporin cefiderocol against multidrug-resistant and extensively drug-resistant Klebsiella pneumoniae from inpatients attending a single hospital in the United Arab Emirates

Background: Cefiderocol (CFDC) is a novel siderophore-cephalosporin, which usually penetrates the bacteria through the iron-uptake pathways. Data is limited on the factors affecting CFDC activity and methods for overcoming resistance development. Synergistic approaches are needed to tackle antimicro...

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Главные авторы:	Lana Daoud, Farah Al-Marzooq, Akela Ghazawi, Febin Anes, Timothy Collyns
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2023-12-01
Серии:	Journal of Infection and Public Health
Предметы:	Klebsiella pneumoniae Cefiderocol β-lactamase inhibitors Polymyxin B nonapeptide Antimicrobial resistance
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S1876034123003908
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