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A GRX1 Promoter Variant Confers Constitutive Noisy Bimodal Expression That Increases Oxidative Stress Resistance in Yeast

Higher noise in the expression of stress-related genes was previously shown to confer better resistance in selective conditions. Thus, evolving the promoter of such genes toward higher transcriptional noise appears to be an attractive strategy to engineer microbial strains with enhanced stress resis...

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Hoofdauteurs: Jian Liu, Delphine Lestrade, Sevan Arabaciyan, Julien Cescut, Jean-Marie François, Jean-Pascal Capp
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2018-09-01
Reeks:Frontiers in Microbiology
Onderwerpen:
stochastic gene expression
Saccharomyces cerevisiae
single-cell analysis
bimodal expression
noise
phenotypic heterogeneity
Online toegang:https://www.frontiersin.org/article/10.3389/fmicb.2018.02158/full
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