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A GRX1 Promoter Variant Confers Constitutive Noisy Bimodal Expression That Increases Oxidative Stress Resistance in Yeast

Higher noise in the expression of stress-related genes was previously shown to confer better resistance in selective conditions. Thus, evolving the promoter of such genes toward higher transcriptional noise appears to be an attractive strategy to engineer microbial strains with enhanced stress resis...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Jian Liu, Delphine Lestrade, Sevan Arabaciyan, Julien Cescut, Jean-Marie François, Jean-Pascal Capp
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018-09-01
Schriftenreihe:Frontiers in Microbiology
Schlagworte:
stochastic gene expression
Saccharomyces cerevisiae
single-cell analysis
bimodal expression
noise
phenotypic heterogeneity
Online-Zugang:https://www.frontiersin.org/article/10.3389/fmicb.2018.02158/full
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