Divergent regulation of cellular cholesterol metabolism by seaweed-derived fucosterol and saringosterol

Marine sterols from brown seaweeds, particularly fucosterol and its oxidized derivative saringosterol, have shown therapeutic potential for Alzheimer’s disease (AD) and cardiovascular diseases. Here, we aimed to elucidate the cellular and in vivo mechanisms underlying their beneficial effects. In hu...

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Bibliografiske detaljer

Principais autores:	Na Zhan, Nikita Martens, Yanlin Li, Gardi Voortman, Frank Leijten, Silvia Friedrichs, Martien P. M. Caspers, Lars Verschuren, Tim Vanmierlo, Marieke Smit, Folkert Kuipers, Johan W. Jonker, Vincent W. Bloks, Marcella Palumbo, Francesca Zimetti, Maria Pia Adorni, Hongbing Liu, Dieter Lütjohann, Monique T. Mulder
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2025-12-01
Serier:	Frontiers in Marine Science
Fag:	fucosterol saringosterol liver X receptors cholesterol homeostasis Alzheimer’s disease
Online adgang:	https://www.frontiersin.org/articles/10.3389/fmars.2025.1728727/full
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