Novel in situ seeding immunodetection assay uncovers neuronal-driven alpha-synuclein seeding in Parkinson’s disease

Abstract Aggregates of alpha-synuclein (α-syn) propagate through template-induced misfolding in people with Parkinson’s disease (PD) and Multiple System Atrophy (MSA). Prion-like seeding is crucial in disease initiation and progression, representing a major target for disease-modifying therapies. Th...

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Detalhes bibliográficos

Principais autores:	Maria Otero-Jimenez, Marcelina J. Wojewska, Simona Jogaudaite, David Miller, Sandra Gray-Rodriguez, Grainne C. Geoghegan, Laura Abelleira-Hervas, Tim James Viney, Barbara Sarkany, Djordje Gveric, Steve Gentleman, Javier Alegre-Abarrategui
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-08-01
coleção:	npj Parkinson's Disease
Acesso em linha:	https://doi.org/10.1038/s41531-025-01111-y
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