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Recent advances in targeting LRRK2 for Parkinson’s disease treatment

Abstract Parkinson’s disease (PD) is a neurodegenerative disease with severe movement problems. Current treatments mainly focus on symptom management by reducing dopaminergic pathways in the brain. Despite these therapies, ongoing disease progression undermines the effectiveness of prevalent approac...

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Principais autores: Mahsa Karami, Pantea Majma Sanaye, Atousa Ghorbani, Roshanak Amirian, Pouya Goleij, Mehregan Babamohamadi, Zhila Izadi
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2025-07-01
סדרה:Journal of Translational Medicine
נושאים:
Parkinson’s disease
LRRK2
Neurodegenerative diseases
Autophagy
PROTAC
Mitochondrial dysfunction
גישה מקוונת:https://doi.org/10.1186/s12967-025-06354-0
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