Recent advances in targeting LRRK2 for Parkinson’s disease treatment

Abstract Parkinson’s disease (PD) is a neurodegenerative disease with severe movement problems. Current treatments mainly focus on symptom management by reducing dopaminergic pathways in the brain. Despite these therapies, ongoing disease progression undermines the effectiveness of prevalent approac...

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Huvudupphov:	Mahsa Karami, Pantea Majma Sanaye, Atousa Ghorbani, Roshanak Amirian, Pouya Goleij, Mehregan Babamohamadi, Zhila Izadi
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2025-07-01
Serie:	Journal of Translational Medicine
Ämnen:	Parkinson’s disease LRRK2 Neurodegenerative diseases Autophagy PROTAC Mitochondrial dysfunction
Länkar:	https://doi.org/10.1186/s12967-025-06354-0
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