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The deubiquitination enzyme USP14 promotes the tumourigenesis of gastric cancer by enhancing c-MYC nuclear translocation through deubiquitination of KPNA2

Abstract The deubiquitinating enzyme USP14, which belongs to the ubiquitin-specific protease family, is highly expressed in various malignant tumors. The regulatory mechanisms in tumors are complex and diverse, encompassing a range of cellular processes such as proliferation, apoptosis, inflammation...

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Hlavní autoři: Jia Li, Houyi Tang, Hongbo Chang, Yi Du, Liang Du, Erhu Zhao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2025-10-01
Edice:Cell Death and Disease
On-line přístup:https://doi.org/10.1038/s41419-025-08065-2
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