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USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer

Abstract Background Mitophagy, essential for cellular homeostasis, is involved in eliminating damaged mitochondria and is associated with cancer progression and chemoresistance. The specific impact of mitophagy on microsatellite instability-high (MSI-H) colorectal cancer (CRC) is still under investi...

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Bibliografische gegevens
Hoofdauteurs: Zhiyong Wang, Cheng Yu, Gengchen Xie, Kaixiong Tao, Zhijie Yin, Qing Lv
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2025-05-01
Reeks:Molecular Medicine
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Online toegang:https://doi.org/10.1186/s10020-025-01182-w
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