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Radicicol as a Dual-Site Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase: A Computational Study

Background: Isoprenylcysteine carboxyl methyltransferase (ICMT) is an enzyme crucial for the post-translational processing of Ras oncoproteins. Pharmacological inhibition of ICMT can mislocalize Ras and disrupt oncogenic signaling, exhibiting anticancer effects. Radicicol (RAD) is a 14-membered reso...

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Principais autores: Sabrin R. M. Ibrahim, Hagar M. Mohamed, Gamal A. Mohamed, Abdelsattar M. Omar
Format: Artigo
Sprog:Inglês
Udgivet: Wolters Kluwer Medknow Publications 2025-10-01
Serier:Journal of Pharmacy and Bioallied Sciences
Fag:
fungi
health and wellbeing
isoprenylcysteine carboxyl methyltransferase
molecular docking
molecular dynamics
radicicol
Online adgang:https://journals.lww.com/10.4103/jpbs.jpbs_1390_25
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