Radicicol as a Dual-Site Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase: A Computational Study
Background: Isoprenylcysteine carboxyl methyltransferase (ICMT) is an enzyme crucial for the post-translational processing of Ras oncoproteins. Pharmacological inhibition of ICMT can mislocalize Ras and disrupt oncogenic signaling, exhibiting anticancer effects. Radicicol (RAD) is a 14-membered reso...
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| Huvudupphov: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Wolters Kluwer Medknow Publications
2025-10-01
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| Serie: | Journal of Pharmacy and Bioallied Sciences |
| Ämnen: | |
| Länkar: | https://journals.lww.com/10.4103/jpbs.jpbs_1390_25 |
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