A Cyclopentanone Compound Attenuates the Over-Accumulation of Extracellular Matrix and Fibrosis in Diabetic Nephropathy via Downregulating the TGF-β/p38MAPK Axis

Excessive accumulation of the extracellular matrix (ECM) is a crucial pathological process in chronic kidney diseases, such as diabetic nephropathy, etc. The underlying mechanisms of how to decrease ECM deposition to improve diabetic nephropathy remain elusive. The present study investigated whether...

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Autores principales:	Chunyin Tang, Meng Wang, Jieting Liu, Chunlei Zhang, Luxin Li, Yan Wu, Yanhui Chu, Dan Wu, Haifeng Liu, Xiaohuan Yuan
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2022-12-01
Colección:	Biomedicines
Materias:	cyclopentanone compound ECM renal fibrosis diabetic nephropathy curcumin analog the TGF-β/p38MAPK signaling pathway
Acceso en línea:	https://www.mdpi.com/2227-9059/10/12/3270
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