A Cyclopentanone Compound Attenuates the Over-Accumulation of Extracellular Matrix and Fibrosis in Diabetic Nephropathy via Downregulating the TGF-β/p38MAPK Axis

Excessive accumulation of the extracellular matrix (ECM) is a crucial pathological process in chronic kidney diseases, such as diabetic nephropathy, etc. The underlying mechanisms of how to decrease ECM deposition to improve diabetic nephropathy remain elusive. The present study investigated whether...

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主要な著者:	Chunyin Tang, Meng Wang, Jieting Liu, Chunlei Zhang, Luxin Li, Yan Wu, Yanhui Chu, Dan Wu, Haifeng Liu, Xiaohuan Yuan
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2022-12-01
シリーズ:	Biomedicines
主題:	cyclopentanone compound ECM renal fibrosis diabetic nephropathy curcumin analog the TGF-β/p38MAPK signaling pathway
オンライン･アクセス:	https://www.mdpi.com/2227-9059/10/12/3270
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