Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome

Congenital short QT syndrome (SQTS) is a repolarization disorder characterized by abbreviated QT intervals, atrial and ventricular arrhythmias and a risk of sudden death. This study characterized a missense mutation (I560T) in the S5 domain of the hERG K+ channel that has been associated with varian...

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Hauptverfasser:	Andrew Butler, Yihong Zhang, A. Graham Stuart, Christopher E. Dempsey, Jules C. Hancox
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2019-04-01
Schriftenreihe:	Heliyon
Schlagworte:	Biophysics Computational biology Physiology
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2405844018354872
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