B Cell Depletion Eliminates FVIII Memory B Cells and Enhances AAV8-coF8 Immune Tolerance Induction When Combined With Rapamycin

Hemophilia A is an inherited coagulation disorder resulting in the loss of functional clotting factor VIII (FVIII). Presently, the most effective treatment is prophylactic protein replacement therapy. However, this requires frequent life-long intravenous infusions of plasma derived or recombinant cl...

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Hlavní autoři:	Moanaro Biswas, Brett Palaschak, Sandeep R. P. Kumar, Jyoti Rana, David M. Markusic
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2020-06-01
Edice:	Frontiers in Immunology
Témata:	hemophilia A inhibitors gene therapy AAV anti-CD20 rapamycin
On-line přístup:	https://www.frontiersin.org/article/10.3389/fimmu.2020.01293/full
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