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B Cell Depletion Eliminates FVIII Memory B Cells and Enhances AAV8-coF8 Immune Tolerance Induction When Combined With Rapamycin

Hemophilia A is an inherited coagulation disorder resulting in the loss of functional clotting factor VIII (FVIII). Presently, the most effective treatment is prophylactic protein replacement therapy. However, this requires frequent life-long intravenous infusions of plasma derived or recombinant cl...

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Principais autores: Moanaro Biswas, Brett Palaschak, Sandeep R. P. Kumar, Jyoti Rana, David M. Markusic
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2020-06-01
סדרה:Frontiers in Immunology
נושאים:
hemophilia A
inhibitors
gene therapy
AAV
anti-CD20
rapamycin
גישה מקוונת:https://www.frontiersin.org/article/10.3389/fimmu.2020.01293/full
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