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Synergism between IL-33 and MRGPRX2/FcεRI Is Primarily Due to the Complementation of Signaling Modules, and Only Modestly Supplemented by Prolonged Activation of Selected Kinases

Skin mast cells (MCs) express high levels of MRGPRX2, FcεRI, and ST2, and vigorously respond to their ligands when triggered individually. IL-33/ST2 also potently synergizes with other receptors, but the molecular underpinnings are poorly understood. Human skin-derived MCs were stimulated via differ...

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Principais autores: Kristin Franke, Zhuoran Li, Gürkan Bal, Torsten Zuberbier, Magda Babina
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-11-01
Serier:Cells
Fag:
mast cells
IL-33
FcεRI
MRGPRX2
TNF-α
p38
Online adgang:https://www.mdpi.com/2073-4409/12/23/2700
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