Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma

Abstract: Chimeric antigen receptor (CAR) T cells (CARTs) have shown tremendous potential for the treatment of certain B-cell malignancies, including patients with relapsed/refractory multiple myeloma (MM). Targeting the B-cell maturation antigen (BCMA) has produced the most promising results for CA...

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Bibliographic Details

Main Authors:	Andrea Schmidts, Maria Ormhøj, Bryan D. Choi, Allison O. Taylor, Amanda A. Bouffard, Irene Scarfò, Rebecca C. Larson, Matthew J. Frigault, Kathleen Gallagher, Ana P. Castano, Lauren S. Riley, Maria L. Cabral, Angela C. Boroughs, Rubí M.-H. Velasco Cárdenas, Wolfgang Schamel, Jing Zhou, Sean Mackay, Yu-Tzu Tai, Kenneth C. Anderson, Marcela V. Maus
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2019-11-01
Series:	Blood Advances
Online Access:	http://www.sciencedirect.com/science/article/pii/S2473952920317869
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