Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma

Abstract: Chimeric antigen receptor (CAR) T cells (CARTs) have shown tremendous potential for the treatment of certain B-cell malignancies, including patients with relapsed/refractory multiple myeloma (MM). Targeting the B-cell maturation antigen (BCMA) has produced the most promising results for CA...

Полное описание

Библиографические подробности

Главные авторы:	Andrea Schmidts, Maria Ormhøj, Bryan D. Choi, Allison O. Taylor, Amanda A. Bouffard, Irene Scarfò, Rebecca C. Larson, Matthew J. Frigault, Kathleen Gallagher, Ana P. Castano, Lauren S. Riley, Maria L. Cabral, Angela C. Boroughs, Rubí M.-H. Velasco Cárdenas, Wolfgang Schamel, Jing Zhou, Sean Mackay, Yu-Tzu Tai, Kenneth C. Anderson, Marcela V. Maus
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2019-11-01
Серии:	Blood Advances
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2473952920317869
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