Combination of astragalus polysaccharide with Diosbulbin B exerts an enhanced antitumor effect in BRAF mut papillary thyroid cancer with decreased liver toxicity

Abstract Background Diosbulbin B (DB) is a traditional Chinese medicine used for thyroid cancer treatment, but always brings severe liver injury. In the current study, we investigated the role of astragalus polysaccharide (APS) in DB-induced hepatotoxicity and their anti-tumor effect on BRAF mut pap...

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Hauptverfasser:	Shuai Xu, Qi Liang, Hang Li, Hai Zhou, Zhenyuan Xu, Yanjun Yan, Yue Zhang, Renqun Ye, Xujun You
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-07-01
Schriftenreihe:	Cancer Cell International
Schlagworte:	BRAF mut papillary thyroid cancer Liver injury Astragalus polysaccharide Diosbulbin B Ferroptosis
Online-Zugang:	https://doi.org/10.1186/s12935-025-03853-4
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