Maintenance of Sertoli Cell Number and Function in Immature Human Testicular Tissues Exposed to Platinum-Based Chemotherapy—Implications for Fertility Restoration

Background: Retrospective studies in adult survivors of childhood cancer show long-term impacts of exposure to alkylating chemotherapy on future fertility. We recently demonstrated germ cell loss in immature human testicular tissues following exposure to platinum-based chemotherapeutic drugs. This s...

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Autores principales:	Gabriele Matilionyte, Melissa D. Tharmalingam, Iris Sanou, Federica Lopes, Sheila Lane, Jan-Bernd Stukenborg, Norah Spears, Richard A. Anderson, Rod T. Mitchell
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2022-03-01
Colección:	Frontiers in Toxicology
Materias:	human testis cisplatin carboplatin sertoli cells pre-pubertal
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/ftox.2022.825734/full
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