A human lung organoid platform for studying radiation-induced pulmonary fibrosis and antifibrotic drug screening

Abstract Radiation-induced pulmonary injury and fibrosis (RIPI/RIPF) is a major complication following thoracic radiotherapy, characterized by persistent inflammation and excessive extracellular matrix deposition leading to irreversible lung disease. The development of antifibrotic drugs has been li...

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Autors principals:	Hae-Ran Park, Yeongkag Kwon, Hyun Jung Ji, Sun-Young Kim, Min-Kyu Kim, Ki Bum Ahn, Ho Seong Seo
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-12-01
Col·lecció:	Scientific Reports
Matèries:	Ionizing radiation Embryonic stem cell Lung organoid Fibrosis Epithelial to mesenchymal transition
Accés en línia:	https://doi.org/10.1038/s41598-025-31582-1
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