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Triorganotin Derivatives Induce Cell Death Effects on L1210 Leukemia Cells at Submicromolar Concentrations Independently of P-glycoprotein Expression

The acceleration of drug efflux activity realized by plasma membrane transporters in neoplastic cells, particularly by P-glycoprotein (P-gp, ABCB1 member of the ABC transporter family), represents a frequently observed molecular cause of multidrug resistance (MDR). This multiple resistance represent...

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Principais autores: Viera Bohacova, Mario Seres, Lucia Pavlikova, Szilvia Kontar, Martin Cagala, Pavel Bobal, Jan Otevrel, Julius Brtko, Zdena Sulova, Albert Breier
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2018-05-01
Serier:Molecules
Fag:
L1210 cells
P-glycoprotein
multidrug resistance
triorganotin derivatives
apoptosis
calcein cell retention
Online adgang:http://www.mdpi.com/1420-3049/23/5/1053
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