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Targeting prokineticin system counteracts hypersensitivity, neuroinflammation, and tissue damage in a mouse model of bortezomib-induced peripheral neuropathy

Abstract Background Neuropathy is a dose-limiting side effect of many chemotherapeutics, including bortezomib. The mechanisms underlying this condition are not fully elucidated even if a contribution of neuroinflammation was suggested. Here, we investigated the role of a chemokine family, the prokin...

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Huvudupphov: Giorgia Moschetti, Giada Amodeo, Daniela Maftei, Roberta Lattanzi, Patrizia Procacci, Patrizia Sartori, Gianfranco Balboni, Valentina Onnis, Vincenzo Conte, Alberto Panerai, Paola Sacerdote, Silvia Franchi
Materialtyp: Artigo
Språk:Inglês
Utgiven: BMC 2019-04-01
Serie:Journal of Neuroinflammation
Ämnen:
Prokineticins
Neuropathic pain
Bortezomib
Neuroinflammation
Macrophages
Länkar:http://link.springer.com/article/10.1186/s12974-019-1461-0
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