Generation and characterization of a novel gne Knockout Model in Zebrafish

GNE Myopathy is a rare, recessively inherited neuromuscular worldwide disorder, caused by a spectrum of bi-allelic mutations in the human GNE gene. GNE encodes a bi-functional enzyme responsible for the rate-limiting step of sialic acid biosynthesis pathway. However, the process in which GNE mutatio...

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Bibliographic Details

Main Authors:	Hagay Livne, Tom Avital, Shmuel Ruppo, Avi Harazi, Stella Mitrani-Rosenbaum, Alon Daya
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	GNE GNE myopathy gne KO zebrafish cell cycle DNA damage repair pathway CRISPR/Cas9
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2022.976111/full
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