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Immunogenicity of a bivalent recombinant adenovirus expressing VP1 proteins of bovine norovirus and bovine nebovirus in mice and calves

Abstract Bovine norovirus (BNoV) and bovine nebovirus (BNeV) are emerging pathogens responsible for severe diarrhea in calves worldwide. In this study, we constructed a bivalent recombinant adenovirus vector vaccine, designated rAd5-BNoV + BNeV_VP1 encoding the genes for BNoV-VP1 and BNeV-VP1 based...

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Principais autores: Taoyun Chen, Jun Chu, Xin Song, Qisheng Yu, Gunan Deng, Jiangyong Zeng, Changqing Yu, Bin Zhang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-12-01
Serier:BMC Microbiology
Fag:
Bovine norovirus
Bovine nebovirus
Replication-deficient human type 5 adenovirus vector
VP1 protein
Immune effects
Online adgang:https://doi.org/10.1186/s12866-025-04542-y
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