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Transcriptomic and genomic analysis of successful Ethiopian Mycobacterium tuberculosis sub-lineage 4.2.2.2 reveals differential expression of DosR-regulated genes

Abstract Mycobacterium tuberculosis (Mtb) sub-lineage 4.2.2.2 is the most frequently isolated strain of Mtb from Ethiopian treatment-refractory tuberculosis patients. This study investigated the underlying molecular background to Mtb sub-lineage 4.2.2.2 through transcriptomic and genomic analyses. C...

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Автори: Tesfaye Gebreyohannis Hailemariam, Abaysew Ayele, Tesfaye Gelanew, Michael Brennan, Kayleigh Floyd, Zemedkun Abebe Debella, Workineh Shibeshi, Kidist Bobosha, Yonas K. Hirutu, Simon J. Waddell, Ephrem Engidawork
Формат: Artigo
Мова:Inglês
Опубліковано: Nature Portfolio 2026-01-01
Серія:Scientific Reports
Предмети:
Mycobacterium tuberculosis sub-lineage 4.2.2.2
DosR regulon
Ethiopia
Whole genome sequencing
Transcriptomics
Онлайн доступ:https://doi.org/10.1038/s41598-025-34471-9
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