Transcriptomic and genomic analysis of successful Ethiopian Mycobacterium tuberculosis sub-lineage 4.2.2.2 reveals differential expression of DosR-regulated genes

Abstract Mycobacterium tuberculosis (Mtb) sub-lineage 4.2.2.2 is the most frequently isolated strain of Mtb from Ethiopian treatment-refractory tuberculosis patients. This study investigated the underlying molecular background to Mtb sub-lineage 4.2.2.2 through transcriptomic and genomic analyses. C...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Tesfaye Gebreyohannis Hailemariam, Abaysew Ayele, Tesfaye Gelanew, Michael Brennan, Kayleigh Floyd, Zemedkun Abebe Debella, Workineh Shibeshi, Kidist Bobosha, Yonas K. Hirutu, Simon J. Waddell, Ephrem Engidawork
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2026-01-01
Цуврал:	Scientific Reports
Нөхцлүүд:	Mycobacterium tuberculosis sub-lineage 4.2.2.2 DosR regulon Ethiopia Whole genome sequencing Transcriptomics
Онлайн хандалт:	https://doi.org/10.1038/s41598-025-34471-9
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!