TadA reprogramming to generate potent miniature base editors with high precision

Hypercompact CRISPR-Cas12f systems have been engineered to generate miniABEs but these have limitations. Here the authors generate Cas12f-derived miniCBEs and develop miniABEs with improved editing and targeting scopes; they use these to correct pathogenic mutations in cell lines and introduce mutat...

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Hlavní autoři:	Shuqian Zhang, Liting Song, Bo Yuan, Cheng Zhang, Jixin Cao, Jinlong Chen, Jiayi Qiu, Yilin Tai, Jingqi Chen, Zilong Qiu, Xing-Ming Zhao, Tian-Lin Cheng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2023-01-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-023-36004-2
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