TadA reprogramming to generate potent miniature base editors with high precision
Hypercompact CRISPR-Cas12f systems have been engineered to generate miniABEs but these have limitations. Here the authors generate Cas12f-derived miniCBEs and develop miniABEs with improved editing and targeting scopes; they use these to correct pathogenic mutations in cell lines and introduce mutat...
Furkejuvvon:
| Váldodahkkit: | , , , , , , , , , , , |
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| Materiálatiipa: | Artigo |
| Giella: | Inglês |
| Almmustuhtton: |
Nature Portfolio
2023-01-01
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| Ráidu: | Nature Communications |
| Liŋkkat: | https://doi.org/10.1038/s41467-023-36004-2 |
| Fáddágilkorat: |
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