Sub-nanomolar sensitivity of nitric oxide mediated regulation of cGMP and vasomotor reactivity in vascular smooth muscle
Nitric oxide (NO) is a potent dilator of vascular smooth muscle (VSM) by modulating intracellular cGMP ([cGMP]i) through the binding and activation of receptor guanylyl cylases (sGC). The kinetic relationship of NO and sGC, as well as the subsequent regulation of [cGMP]i and its effects on blood ve...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Frontiers Media S.A.
2012-07-01
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| Schriftenreihe: | Frontiers in Pharmacology |
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| Online-Zugang: | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00130/full |
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