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Sub-nanomolar sensitivity of nitric oxide mediated regulation of cGMP and vasomotor reactivity in vascular smooth muscle

Nitric oxide (NO) is a potent dilator of vascular smooth muscle (VSM) by modulating intracellular cGMP ([cGMP]i) through the binding and activation of receptor guanylyl cylases (sGC). The kinetic relationship of NO and sGC, as well as the subsequent regulation of [cGMP]i and its effects on blood ve...

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Príomhchruthaitheoirí: Kara F. Held, Wolfgang R. Dostmann
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Frontiers Media S.A. 2012-07-01
Sraith:Frontiers in Pharmacology
Ábhair:
Rochtain ar líne:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00130/full
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