Structure-based discovery of hydrocarbon-stapled paxillin peptides that block FAK scaffolding in cancer

Abstract The focal adhesion kinase (FAK) scaffold provides FAK-targeted cancer therapeutics with greater efficacy and specificity than traditional kinase inhibitors. The FAK scaffold function largely involves the interaction between FAK’s focal adhesion targeting (FAT) domain and paxillin, ultimatel...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Lauren Reyes, Lena Naser, Warren S. Weiner, Darren Thifault, Erik Stahl, Liam McCreary, Rohini Nott, Colton Quick, Alex Buchberger, Carlos Alvarado, Andrew Rivera, Joseph A. Miller, Ruchi Khatiwala, Brian R. Cherry, Ronald Nelson, Jose M. Martin-Garcia, Nicholas Stephanopoulos, Raimund Fromme, Petra Fromme, William Cance, Timothy Marlowe
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2025-02-01
Цуврал:	Nature Communications
Онлайн хандалт:	https://doi.org/10.1038/s41467-025-57196-9
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!