Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells

Copper, a vital mineral nutrient, possesses redox qualities that make it both beneficial and toxic to organisms. Excessive environmental copper exposure can result in neurological damage and cognitive decline in humans. Astrocytes, the predominant glial cells in the brain, are particularly vulnerabl...

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Hlavní autoři:	Wei Shi, Qian Zhou, Lu Lu, Ying Zhang, Hu Zhang, Yuepu Pu, Lihong Yin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-10-01
Edice:	Ecotoxicology and Environmental Safety
Témata:	Copper Astrocyte CGAS-STING Pyroptosis Neurotoxicity
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0147651324011618
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