Causal relationship between sarcopenia with osteoarthritis and the mediating role of obesity: a univariate, multivariate, two-step Mendelian randomization study

Abstract Background Recent genetic evidence supports a causal role for sarcopenia in osteoarthritis, which may be mediated by the occurrence of obesity or changes in circulating inflammatory protein levels. Here, we leveraged publicly available genome-wide association study data to investigate the i...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Zicheng Jin, Rui Wang, Linzi Jin, Lishuang Wan, Yuzhou Li
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2024-05-01
Sarja:	BMC Geriatrics
Aiheet:	Mendelian randomization Knee osteoarthritis Hip osteoarthritis Sarcopenia Obesity Circulating inflammatory proteins
Linkit:	https://doi.org/10.1186/s12877-024-05098-8
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