Causal relationship between sarcopenia with osteoarthritis and the mediating role of obesity: a univariate, multivariate, two-step Mendelian randomization study

Abstract Background Recent genetic evidence supports a causal role for sarcopenia in osteoarthritis, which may be mediated by the occurrence of obesity or changes in circulating inflammatory protein levels. Here, we leveraged publicly available genome-wide association study data to investigate the i...

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Detalles Bibliográficos

Principais autores:	Zicheng Jin, Rui Wang, Linzi Jin, Lishuang Wan, Yuzhou Li
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2024-05-01
Series:	BMC Geriatrics
Assuntos:	Mendelian randomization Knee osteoarthritis Hip osteoarthritis Sarcopenia Obesity Circulating inflammatory proteins
Acceso en liña:	https://doi.org/10.1186/s12877-024-05098-8
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