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Geometry-driven immunomodulation in 3D-printed bioceramics: Negative curvature promotes macrophage M2 polarization via Ras-MAPK/HIF-1α signaling for vascularized osteogenesis

The geometric features of bioactive scaffolds are biophysical cues regulate cell fate, but their immunomodulatory potential in bone regeneration is yet to be determined. Growing evidence suggests that surface curvature is a potent regulator of cellular behaviours and osteogenesis. Therefore, we quan...

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Principais autores: Qiji Lu, Yudi Kuang, Jingjing Diao, Jiaqian Zheng, Naru Zhao, Chang Du, Yingjun Wang
Formato: Artigo
Idioma:Inglês
Publicado: KeAi Communications Co., Ltd. 2026-06-01
Series:Bioactive Materials
Assuntos:
Gaussian curvature
High-throughput screening
Macrophage polarization
Immunomodulatory biomaterials
Bone regeneration
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2452199X26000010
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